你好，我这里有一个临床试验的资料，你可以参考，其实狂苗是历史悠久应用广泛的疫苗，其安全性是经过验证了的。 2000年进行的一项临床试验的报告： 题目：Post-exposure prophylaxis with purified vero cell rabies vaccine during pre...gnancy--safety and immunogenicity. 摘要：This study was conducted with the main objective of determining the safety and immunogenicity of purified vero cell rabies vaccine (PVRV) during pregnancy. Twenty nine pregnant women exposed to rabies were vaccinated with PVRV as per the Essen regimen advocated by World Health Organization. None of the women experienced any adverse side effects to the vaccine. The intrauterine growth and development monitored by ultrasound examination was found to be normal and the outcome of pregnancy was satisfactory. There were no congenital anomalies in any of the infants born and they were healthy and had normal growth and development during the one year follow-up period. The rabies neutralizing antibody titers from day 14 to day 365 following vaccination in these women was adequate and well above the minimum protective level of 0.5 iu/ml of serum. Protective levels of antibodies were also present in serum of some of the babies tested, for up to 3 months of age. The mothers and infants followed for one year period were doing well at the end of the study period. Consequently, PVRV was found safe and immunogenically efficacious during pregnancy. 中文简介：29个孕期妇女进行Vero 细胞狂苗的暴露后治疗免疫。没有发现疫苗的不良反应。胎儿的宫内生长发育用B超检查正常，孕期表现令人满意。出生的婴儿未发现任何先天畸形，在随后的一年随访期中生长发育正常。孕妇血清的狂犬病毒中和滴度正常，有些婴儿在出生3个月内能检出抗狂犬病毒抗体。在一年的研究期中，所有试验包括的母子均健康。认为Vero 细胞狂苗对孕期妇女是安全有效的。